16 - CAFFEINE

Caffeine! Everyone's favorite psychoactive drug. Is caffeine good or bad for you? This episode of This Won't Hurt A Bit we shall discuss how caffeine works, and whether there are any health benefits. We will also explore what happens when you have too much caffeine.


SHOW NOTES

SCIENTIFIC REFERENCES

  • American College of Obstetricians and Gynecologists. ACOG Committee Opinion No. 462: Moderate caffeine consumption during pregnancy. Obstetrics and gynecology. 2010 Aug;116(2 Pt 1):467.

  • American College of Obstetricians and Gynecologists. Frequently Asked Questions: Labor, Delivery, and Postpartum Care. June 2013. http://www.acog.org/~/media/For%20Patients/faq029.pdf

  • Maridakis V, O’Connor PJ, Dudley GA, McCully KK. Caffeine attenuates delayed-onset muscle pain and force loss following eccentric exercise. The Journal of Pain. 2007 Mar 31;8(3):237-43.

  • Graham TE, Rush JW, Soeren MH. Caffeine and exercise: metabolism and performance. Canadian Journal of Applied Physiology. 1994 Jun 1;19(2):111-38.

  • Basurto Ona X, Osorio D, Bonfill Cosp X. Drug therapy for treating post-dural puncture headache. status and date: Stable (no update expected for reasons given in ’What’s new’), published in. 2015 Jan 1(7).

  • Smith A, Sutherland D, Christopher G. Effects of repeated doses of caffeine on mood and performance of alert and fatigued volunteers. Journal of Psychopharmacology. 2005 Nov 1;19(6):620-6.

  • Bordeaux B, Lieberman HR. Benefits and risks of caffeine and caffeinated beverages. In: UpToDate, Lipman TO (Ed), UpToDate, Waltham, MA, 2015.

  • Diener HC, Gold M, Hagen M. Use of a fixed combination of acetylsalicylic acid, acetaminophen and caffeine compared with acetaminophen alone in episodic tension-type headache: meta-analysis of four randomized, double-blind, placebo-controlled, crossover studies. The journal of headache and pain. 2014 Dec 1;15(1):1-0.

  • Hernán MA, Takkouche B, Caamaño‐Isorna F, Gestal‐Otero JJ. A meta‐analysis of coffee drinking, cigarette smoking, and the risk of Parkinson's disease. Annals of neurology. 2002 Sep 1;52(3):276-84.

  • Quintana JL, Allam MF, Del Castillo AS, Navajas RF. Alzheimer's disease and coffee: a quantitative review. Neurological research. 2007 Jan 1;29(1):91-5.

  • Lazarus M, Shen HY, Cherasse Y, Qu WM, Huang ZL, Bass CE, Winsky-Sommerer R, Semba K, Fredholm BB, Boison D, Hayaishi O. Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens. The Journal of Neuroscience. 2011 Jul 6;31(27):10067-75.

  • Huang ZL, Zhang Z, Qu WM. Roles of adenosine and its receptors in sleep-wake regulation. Int Rev Neurobiol. 2014 Jan 1;119:349-71.

  • Goldstein J, Silberstein SD, Saper JR, et al. Acetaminophen, aspirin, and caffeine in combination versus ibuprofen for acute migraine: results from a multicenter, double-blind, randomized, parallel-group, single-dose, placebo-controlled study. Headache 2006; 46:444.

  • Diener HC, Gold M, Hagen M. Use of a fixed combination of acetylsalicylic acid, acetaminophen and caffeine compared with acetaminophen alone in episodic tension-type headache: meta-analysis of four randomized, double-blind, placebo-controlled, crossover studies. J Headache Pain 2014; 15:76.

  • Fredholm BB, Bättig K, Holmén J, Nehlig A, Zvartau EE. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacological reviews. 1999 Mar 1;51(1):83-133.

  • Basheer R, Strecker RE, Thakkar MM, McCarley RW. Adenosine and sleep–wake regulation. Progress in neurobiology. 2004 Aug 31;73(6):379-96.

  • Martin R. Management of Apnea of Prematurity. In: UpToDate, Garcia-Prats JA, Mallory GB (Ed), UpToDate, Waltham, MA, 2015.

  • Camman WR, Murray S, Mushlin PS, Lambert DH, Dewan DM. Effects of Oral Caffeine on Postdural Puncture Headache A Double-Blind, Placebo-Controlled Trial. Obstetric Anesthesia Digest. 1990 Oct 1;10(3):167.

INTERVIEWS

  • Yates, Steven. (2016, February). Personal Interview.

SOUND CLIPS

OTHER REFERENCES

ABC News Video: Parents Make Plea to Lawmakers to Pull Caffeine Powder From the Market (1:43 mins).

ABC News Video: Parents Make Plea to Lawmakers to Pull Caffeine Powder From the Market (1:43 mins).

History Channel Modern Marvels: The Sweet History of Chocolate (1:14)

History Channel Modern Marvels: The Sweet History of Chocolate (1:14)